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Biomaterials tailored for Sound Induced Morphogenesis

KYTO

KYTO is a chemically defined, synthetic hydrogel that bears biologically active sites. An MMP-cleavable crosslinker allows for potential cell spreading and migration.

The hydrogel can be customised to bear a cell adhesive peptide, RGD, to further fine-tune the properties for specific applications.

KYTO increases in viscosity after 8 to 10 minutes, enabling a dense and well-defined cell pattern to be formed followed by enhanced stability of the pattern when the dish is moved from cymatiX to the incubator for complete gelation.

Kyto

Tissue Engineering and in vitro models
In vitro vasculogenesis
Multicellular systems
Morphogenesis and tissue formation

The main components of this hydrogel are SG-Dextran and CD-link crosslinker. When combined, these two components form stable thioether bonds. The CD-link bears MMP cleavable sites which allows for potential cell spreading and migration.

At a crosslinking strength of 2 mmol/L and at room temperature, the hydrogel can be used for patterning for 2 to 6 minutes. Complete gelation is achieved within 10 to 30 minutes or by placing the gel in the incubator at 37°C.

Crosslinking strength and final mechanical properties can be tuned by varying the SG-Dextran and CD-link concentration. Gelation kinetics can be adjusted by changing the pH (optional product 10x CB buffer at pH 5.5.).

The hydrogel can also be prepared with a thiol-functionalised RGD peptide that covalently binds to the SG-Dextran.

LUMPO

LUMPO is a chemically defined, synthetic hydrogel that crosslinks upon irradiation at 405 nm.

This hydrogel does not bear any biologically active sites. The viscosity has been optimised to allow for prolonged patterning of single cells or particles.

Gelation on demand is ideal to exploit the method of sound induced morphogenesis.

The playground for explorers!

Evaluation and optimisation of patterning parameters with cells or particles
Cell patterning and cell condensation
Self-assembly of spheroids
Stem cell differentiation in aggregates
In vitro models and pharmaceutical evaluations

The main components of this hydrogel are N-Dextran and PEG-link crosslinker.

Dextran is functionalised with a photosensitive norbornene group (N) that reacts with the thiol groups of the PEG-link upon addition of the photoinitiator LAP and when irradiated at 405 nm.

Gelation is therefore induced upon demand, guaranteeing a long-lasting patterning experience and the possibility to exploit different patterning parameters.

Crosslinking strength and final mechanical properties can be tuned by varying the N-Dextran and PEG-link concentration.

BAKU

BAKU is a chemically defined, synthetic hydrogel based on Dextran and PEG.

This hydrogel does not bear any biologically active sites.

Viscosity and gelation kinetics were adapted to allow for patterning of individual cells or particles.

Cell patterning and cell condensation
Self-assembly of spheroids
Stem cell differentiation in aggregates
In vitro models and pharmaceutical evaluations

The main components of this hydrogel are SG-Dextran and PEG-link crosslinker.

When combined, these two components form stable thioether bonds. At a crosslinking strength of 2 mmol/L and at room temperature, the hydrogel can be used for patterning for at least 10 minutes to 10 to 15 minutes until an increase in viscosity is observed.

Complete gelation is achieved within 30 minutes by placing the gel in the incubator at 37°C. Crosslinking strength and final mechanical properties can be tuned by varying the SG-Dextran and PEG-link concentration.

ZAVA

ZAVA is a chemically defined, synthetic hydrogel that allows you to exploit the full potential of SIM – long term patterning, gelation upon demand, and biologically active sites.

The hydrogel is photosensitive and crosslinks upon irradiation at 405 nm.

MMP-cleavable sites and RGD peptides allow for potential cell spreading and migration and promote cell adhesion.

Tissue Engineering and in vitro models
In vitro vasculogenesis
Multicellular systems
Morphogenesis and tissue formation

The main components of this hydrogel are RGD-N-Dextran and CD-link crosslinker. Dextran is functionalised with a photosensitive norbornene group (N) that reacts with the thiol groups of the CD-link upon addition of the photoinitiator LAP and when irradiated at 405 nm.

Gelation is therefore induced upon demand, guaranteeing a long-lasting patterning experience and the possibility to exploit different patterning parameters.

The CD-link bears MMP cleavable sites which allows for potential cell spreading and migration.

Crosslinking strength and final mechanical properties can be tuned by varying the RGD-N-Dextran and CD-link concentration.

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