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I'M AN ORIGINAL CATCHPHRASE

OUR TECHNOLOGY

Sound Induced Morphogenesis

Biologicals – Cells, spheroids, organoids- or non-biological particles are dispersed in a hydrogel precursor and loaded in the SIM carrier.

 

A vertical vibration generated with sound is applied, and a pattern is generated within seconds.

 

Crosslinking of the patterned particulates within the hydrogel is carried out by using different stimuli (light, enzymatic, thermal crosslinking) depending on the material. Multiple differently patterned layers can be built sequentially.

Fast creation of multicellular architectures

FAST

Create multicellular architectures within seconds

Cell friendly and contactless process

CELL FRIENDLY

Contactless & mild process. Phenotype cell viability & metabolic activity preserved

accelerate the research and development of biofabrication

ACCELERATOR

Expand the field of biofabrication while leveraging common knowledge

simple bilofabrication process

SIMPLICITY

Create architectures of materials of choice with a large bank of sound profiles

 

AN EMERGING TECHNOLOGY TO EXPLOIT YOUR CREATIVITY

PATTERNING OF LIVING BUILDING BLOCKS

  • Cells

  • Speroids

  • Organoids

  • Micrografts

cell pattern in circles
calcium phosphate cymatics patterns

PATTERNING OF PARTICLES

  • Calcium phosphate

  • Hydrogel precursors

  • Polymer microbeads

zoom on vascular cell patterning
cell pattern in circle with vascularization
  • Controlled condensation and defined wide length scale, from micrometer to centimeter

  • Cell friendly, contact-less and gentle process that does not impair cell viability and metabolic activity

HIGHLY VERSATILE

Your hydrogel, your cells, your application

INFINITE POSSIBILITIES

Multi-cellular and multi-layered architectures

OPEN-END COMPLEXITY

Physiologically relevant in vitro models can be developed

PUBLICATIONS

Sound-induced morphogenesis of multicellular systems for rapid orchestration of vascular networks.

 

Biofabrication (2020)

Biotunable acoustic node assembly of organoids.

 

Advanced Healthcare Materials (2015)

Engineering Anisotropic Muscle Tissue using Acoustic Cell Patterning.

Advanced Materials (2018)

Micro-scale assembly directed by liquid.

 

template.Advanced Materials (2014)

Surface waves control bacterial attachment and formation of biofilms in thin layers.

Science Advances  (2020)

Audible sound-controlled spatiotemporal patterns in out-of equilibrium systems.

Nat. Chem. (2020)