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Sound Induced Morphogenesis
Biologicals – Cells, spheroids, organoids- or non-biological particles are dispersed in a hydrogel precursor and loaded in the SIM carrier.
A vertical vibration generated with sound is applied, and a pattern is generated within seconds.
Crosslinking of the patterned particulates within the hydrogel is carried out by using different stimuli (light, enzymatic, thermal crosslinking) depending on the material. Multiple differently patterned layers can be built sequentially.
Create multicellular architectures within seconds
Contactless & mild process. Phenotype cell viability & metabolic activity preserved
Expand the field of biofabrication while leveraging common knowledge
Create architectures of materials of choice with a large bank of sound profiles
AN EMERGING TECHNOLOGY TO EXPLOIT YOUR CREATIVITY
PATTERNING OF LIVING BUILDING BLOCKS
PATTERNING OF PARTICLES
Controlled condensation and defined wide length scale, from micrometer to centimeter
Cell friendly, contact-less and gentle process that does not impair cell viability and metabolic activity
Your hydrogel, your cells, your application
Multi-cellular and multi-layered architectures
Physiologically relevant in vitro models can be developed
Sound-induced morphogenesis of multicellular systems for rapid orchestration of vascular networks.
Biotunable acoustic node assembly of organoids
Advanced Healthcare Materials (2015)
Micro-scale assembly directed by liquid template.
Advanced Materials (2014)
Surface waves control bacterial attachment and formation of biofilms in thin layers.
Science Advances (2020)
Engineering Anisotropic Muscle Tissue using Acoustic Cell Patterning
Advanced Materials (2018)
Audible sound-controlled spatiotemporal patterns in out-of equilibrium systems
Nat. Chem. (2020)
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