I'M AN ORIGINAL CATCHPHRASE
A GAME-CHANGING TECHNOLOGY
SOUND INDUCED MORPHOGENESIS
Controlled remotely by acoustic waves, Sound Induced Morphogenesis (SIM) allows to pattern biological material such as cells, organoids, or tissue fragments into three-dimensional constructs that develop into engineered tissues, for example microvascular networks.
SIM is an exclusive process to reproduce the fundamental steps of nature’s design strategy: condensing bioactives and pattern formation control.
Patterning of living
Cells, Spheroids, Organoids, Micrografts
Patterning of particles
Calcium phosphate, Hydrogel precursors, Polymer microbeads
Controlled condensation and defined wide length scale, from micrometer to centimeter.
Cell friendly, contact-less process that does not impair cell viability and metabolic activity.
A process that speaks the industrial language.
Create multicellular architectures within seconds
Contactless & mild process. Phenotype cell viability & metabolic activity preserved
Create architectures of materials of choice with a large bank of sound profiles
Our SIM-Discovery tool
Creates physiologically relevant engineered tissue constructs and in vitro models
Allows full control
Overcome majors challenges by controlling cell density enhancement and pattern formation
Standalone & Compact
Compatible with any lab hood or biosafety cabinet
Evolutive & upgradable architecture with cross linking, thermal management and predictive design tools
Sound-based assembly of a microcapillary network in a saturn-like tumor model for drug testing
The tumor microenvironment (TME), consisting of extracellular matrix, proteins, stromal cells, and a vascular system, is reported to have a key role in cancer progression and prognosis. Thereby, the interaction between...
Engineering Anisotropic Muscle Tissue using Acoustic Cell Patterning
Advanced Materials (2018)
Tissue engineering has offered unique opportunities for disease modeling and regenerative medicine; however, the success of these strategies is dependent on faithful reproduction of native cellular organization. Here, it is reported that...
Audible sound-controlled spatiotemporal patterns in out-of equilibrium systems
Nature Chemistry (2020)
Naturally occurring spatiotemporal patterns typically have a predictable pattern design and are reproducible over several cycles. However, the patterns obtained from artificially designed out-of-equilibrium chemical...