I'M AN ORIGINAL CATCHPHRASE
A GAME-CHANGING TECHNOLOGY
SOUND INDUCED MORPHOGENESIS
Controlled remotely by acoustic waves, Sound Induced Morphogenesis (SIM) allows to pattern biological material such as cells, organoids, or tissue fragments into three-dimensional constructs that develop into engineered tissues, for example microvascular networks.
SIM is an exclusive process to reproduce the fundamental steps of nature’s design strategy: condensing bioactives and pattern formation control.
Cell condensation
Pattern formation
Patterning of living
building blocks
Cells, Spheroids, Organoids, Micrografts
Patterning of particles
Calcium phosphate, Hydrogel precursors, Polymer microbeads
Versatile
Controlled condensation and defined wide length scale, from micrometer to centimeter.
Gentle
Cell friendly, contact-less process that does not impair cell viability and metabolic activity.
Scalable
A process that speaks the industrial language.
FAST
Create multicellular architectures within seconds
CELL FRIENDLY
Contactless & mild process. Phenotype cell viability & metabolic activity preserved
SIMPLE
Create architectures of materials of choice with a large bank of sound profiles
CymatiX™
Our SIM-Discovery tool
Overcomes limitations
Creates physiologically relevant engineered tissue constructs and in vitro models
Allows full control
Overcome majors challenges by controlling cell density enhancement and pattern formation
Standalone & Compact
Compatible with any lab hood or biosafety cabinet
Customisable
Evolutive & upgradable architecture with cross linking, thermal management and predictive design tools
Applications
Publications
Sound-based assembly of a microcapillary network in a saturn-like tumor model for drug testing
ScienceDirect (2022)
The tumor microenvironment (TME), consisting of extracellular matrix, proteins, stromal cells, and a vascular system, is reported to have a key role in cancer progression and prognosis. Thereby, the interaction between...
Surface waves control bacterial attachment and formation of biofilms in thin layers
Science Advances (2020)
Formation of bacterial biofilms on solid surfaces within a fluid starts when bacteria attach to the substrate. Understanding environmental factors affecting the attachment and...
Engineering Anisotropic Muscle Tissue using Acoustic Cell Patterning
Advanced Materials (2018)
Tissue engineering has offered unique opportunities for disease modeling and regenerative medicine; however, the success of these strategies is dependent on faithful reproduction of native cellular organization. Here, it is reported that...
Audible sound-controlled spatiotemporal patterns in out-of equilibrium systems
Nature Chemistry (2020)
Naturally occurring spatiotemporal patterns typically have a predictable pattern design and are reproducible over several cycles. However, the patterns obtained from artificially designed out-of-equilibrium chemical...
Micro-scale assembly directed by liquid
Advanced Materials (2014)
A liquid surface established by standing waves is used as a dynamically reconfigurable template to assemble microscale materials into ordered, symmetric structures in a scalable and parallel manner.
Biotunable acoustic node assembly of organoids
Advanced Healthcare Materials (2015)
Bioengineering of 3D microtissues from cell spheroids is demonstrated by employing the vibration of acoustic standing waves and its hydrodynamic effect at the bottom of a liquid-carrier chamber.