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OUR TECHNOLOGY

Sound Induced Morphogenesis

Biologicals – Cells, spheroids, organoids- or non-biological particles are dispersed in a hydrogel precursor and loaded in the SIM carrier.

A vertical vibration generated with sound is applied, and a pattern is generated within seconds.

Crosslinking of the patterned particulates within the hydrogel is carried out by using different stimuli (light, enzymatic, thermal crosslinking) depending on the material. Multiple differently patterned layers can be built sequentially.

FAST

Create multicellular architectures within seconds

CELL FRIENDLY

Contactless & mild process. Phenotype cell viability & metabolic activity preserved

ACCELERATOR

Expand the field of biofabrication while leveraging common knowledge

SIMPLICITY

Create architectures of materials of choice with a large bank of sound profiles

AN EMERGING TECHNOLOGY TO EXPLOIT YOUR CREATIVITY

PATTERNING OF LIVING BUILDING BLOCKS

• Cells

• Speroids

• Organoids

• Micrografts

PATTERNING OF PARTICLES

• Calcium phosphate

• Hydrogel precursors

• Polymer microbeads

• Controlled condensation and defined wide length scale, from micrometer to centimeter

• Cell friendly, contact-less and gentle process that does not impair cell viability and metabolic activity

INFINITE POSSIBILITIES

Multi-cellular and multi-layered architectures

OPEN-END COMPLEXITY

Physiologically relevant in vitro models can be developed

PUBLICATIONS

Sound-induced morphogenesis of multicellular systems for rapid orchestration of vascular networks.

Biofabrication (2020)

Biotunable acoustic node assembly of organoids

Advanced Healthcare Materials (2015)

Micro-scale assembly directed by liquid template.

Advanced Materials (2014)

Surface waves control bacterial attachment and formation of biofilms in thin layers.

Science Advances  (2020)

Engineering Anisotropic Muscle Tissue using Acoustic Cell Patterning

Advanced Materials (2018)

Audible sound-controlled spatiotemporal patterns in out-of equilibrium systems

Nat. Chem. (2020)

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Interested in advancing bioprinting?

Contact us!

mimiX Biotherapeutics

Rue de la Pierre-à-Mazel 39

Case postale Microcity

2000 Neuchâtel