ZAVA
ZAVA is a chemically defined, synthetic hydrogel that allows you to exploit the full potential of SIM – long term patterning, gelation upon demand, and biologically active sites. The hydrogel is photosensitive and crosslinks upon irradiation at 405 nm. MMP-cleavable sites and RGD peptides allow for potential cell spreading and migration and promote cell adhesion.
Application
Cell migration. Cell spreading. Gelation upon demand. ZAVA has it all!
Tissue Engineering and in vitro models
In vitro vasculogenesis
Multicellular systems
Morphogenesis and tissue formation
Description
The main components of this hydrogel are RGD-N-Dextran and CD-link crosslinker. Dextran is functionalised with a photosensitive norbornene group (N) that reacts with the thiol groups of the CD-link upon addition of the photoinitiator LAP and when irradiated at 405 nm.
Gelation is therefore induced upon demand, guaranteeing a long-lasting patterning experience and the possibility to exploit different patterning parameters.
The CD-link bears MMP cleavable sites which allows for potential cell spreading and migration. Crosslinking strength and final mechanical properties can be tuned by varying the RGD-N-Dextran and CD-link concentration.
1 contains 1ml